Doctor Ye Pingan (Liu Shishi) went to the Holy City for an old case. Because of her scheming, she was regarded as a "witch" and avoided by everyone. Yuan Shaocheng (Dou Xiao), the Prime Minister of Dali Temple, was born in the Manggou untouchable area. He was cold and cruel, and always seized the opportunity to climb up. At this time, a murder case broke out in the Holy City, and an official of the imperial court died tragically at home. Ye Pingan had treated him for insomnia and happened to be at the scene of the murder, so he was regarded as the murderer. Yuan Shaocheng saw that the case was strange, but still put Ye Pingan to death as a "letter of surrender" for his promotion. But no one could have imagined that Ye Pingan had already made the first move on her road to revenge.